abstract：BACKGROUND:The reported prevalence and degrees of Demodex mite infestation in rosacea vary widely. OBJECTIVE:We sought to conduct an evidence-based meta-analysis of the prevalence and degrees of Demodex mite infestation in patients with rosacea. METHODS:Systematic literature review and meta-analysis were conducted. O...

journal_title：Journal of the American Academy of Dermatology

authors： Chang YS,Huang YC

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Detecting a more advanced stage of the primary melanoma after wide local excision and reconstruction can complicate patient counseling about prognosis, management of surgical margins, and indications for sentinel lymph node biopsy. OBJECTIVE:To identify the frequency of and risk factors associated with upst...

journal_title：Journal of the American Academy of Dermatology

authors： Etzkorn JR,Sharkey JM,Grunyk JW,Shin TM,Sobanko JF,Miller CJ

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Despite multiple therapeutic approaches for nephrogenic systemic fibrosis (NSF), no single treatment has convincingly shown consistent benefit. The most successful outcomes have been associated with recovery of renal function, although evidence remains limited and past studies have been inconclusive. OBJECT...

journal_title：Journal of the American Academy of Dermatology

authors： Wilson J,Gleghorn K,Seigel Q,Kelly B

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Chronic cutaneous lupus erythematosus (CCLE) often affects the scalp resulting in scarring alopecia. While histopathologic findings of CCLE have been well described, there is little written on the morphologic changes to the hair follicles in this condition. OBJECTIVE:We aim to determine the histopathologic ...

journal_title：Journal of the American Academy of Dermatology

authors： Chung HJ,Goldberg LJ

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:It is unclear whether patients with atopic dermatitis (AD) have an altered prevalence or risk for contact sensitization. Increased exposure to chemicals in topical products together with impaired skin barrier function suggest a higher risk, whereas the immune profile suggests a lower risk. OBJECTIVE:To perf...

journal_title：Journal of the American Academy of Dermatology

authors： Hamann CR,Hamann D,Egeberg A,Johansen JD,Silverberg J,Thyssen JP

更新日期：2017-07-01 00:00:00

abstract：:Vitiligo is a common autoimmune disease that progressively destroys melanocytes in the skin, resulting in the appearance of patchy depigmentation. This disfiguring condition frequently affects the face and other visible areas of the body, which can be psychologically devastating. The onset of vitiligo often occurs in ...

journal_title：Journal of the American Academy of Dermatology

authors： Rodrigues M,Ezzedine K,Hamzavi I,Pandya AG,Harris JE,Vitiligo Working Group.

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Concern has been raised about the potential long-term effects of propranolol treatment for infantile hemangioma (IH). OBJECTIVES:We sought to assess psychologic (social, emotional, behavioral, and executive) functioning in children treated with propranolol for IH. METHODS:Twenty-seven patients with IH (6.1...

journal_title：Journal of the American Academy of Dermatology

authors： Moyakine AV,Spillekom-van Koulil S,van der Vleuten CJM

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Effective medical treatment for patients with severe hidradenitis suppurativa (HS) is limited. OBJECTIVES:We sought to measure the impact of wide local excision on quality of life in HS Hurley grade III patients and to examine the rate of postoperative complications, disease recurrences, and satisfaction wi...

journal_title：Journal of the American Academy of Dermatology

authors： Posch C,Monshi B,Quint T,Vujic I,Lilgenau N,Rappersberger K

更新日期：2017-07-01 00:00:00

abstract：:With the introduction of the Medicare Access and Children's Health Insurance Program Reauthorization Act, clinicians who are not eligible for an exemption must choose to participate in 1 of 2 new reimbursement models: the Merit-based Incentive Payment System or Alternative Payment Models (APMs). Although most dermatol...

journal_title：Journal of the American Academy of Dermatology

authors： Barbieri JS,Miller JJ,Nguyen HP,Forman HP,Bolognia JL,VanBeek MJ,Group for Research of Policy Dynamics in Dermatology.

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Although only large congenital melanocytic nevi (CMN) are associated with a significantly high risk for malignant transformation, CMN of all sizes are prone to changes in clinical appearance in early childhood and thus are often biopsied or excised. While CMNs typically exhibit benign behavior, atypical hist...

journal_title：Journal of the American Academy of Dermatology

authors： Simons EA,Huang JT,Schmidt B

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Vitiligo is an autoimmune disease of the skin with limited treatment options; there is an urgent need to identify and validate biomarkers of disease activity to support vitiligo clinical studies. OBJECTIVE:To investigate potential biomarkers of disease activity directly in the skin of vitiligo subjects and ...

journal_title：Journal of the American Academy of Dermatology

authors： Strassner JP,Rashighi M,Ahmed Refat M,Richmond JM,Harris JE

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Garment-related terms have been used to describe the pattern of distribution of giant congenital melanocytic nevi (GCMN). OBJECTIVE:We sought to describe patterns of distribution of GCMN and propose a classification scheme. METHODS:Photographic records of patients with GCMN from the Hospital Clinic of Barc...

journal_title：Journal of the American Academy of Dermatology

authors： Martins da Silva VP,Marghoob A,Pigem R,Carrera C,Aguilera P,Puig-Butillé JA,Puig S,Malvehy J

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:The hair pull test lacks validation and has unclear pretest guidelines. OBJECTIVE:We sought to quantify normal hair pull test values and elucidate the effect of pretest hair washing and brushing. The impact of hair texture and lifestyle was also examined. METHODS:Participants (n = 181) completed a question...

journal_title：Journal of the American Academy of Dermatology

authors： McDonald KA,Shelley AJ,Colantonio S,Beecker J

更新日期：2017-03-01 00:00:00

abstract：:As summarized in the first article in this continuing medical education series, the currently available epidemiologic data suggest that psoriasis may be a risk factor for cardiometabolic disease. Emerging data also suggest associations between psoriasis and other comorbidities beyond psoriatic arthritis, including chr...

journal_title：Journal of the American Academy of Dermatology

authors： Takeshita J,Grewal S,Langan SM,Mehta NN,Ogdie A,Van Voorhees AS,Gelfand JM

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Epidermolysis bullosa simplex is a skin-blistering disorder caused by mutations in keratin (K)14 or K5. Treatment with nuclear factor (erythroid-derived 2)-like 2 inducer sulforaphane ameliorated skin blistering in Krt14-null mice, correlating with induction of K17. To be therapeutically useful for epidermol...

journal_title：Journal of the American Academy of Dermatology

authors： Kerns ML,Guss L,Fahey J,Cohen B,Hakim JM,Sung S,Lu RG,Coulombe PA

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Guselkumab, an interleukin-23 blocker, was superior to adalimumab in treating moderate to severe psoriasis in a phase II trial. OBJECTIVES:We sought to compare efficacy and safety of guselkumab with adalimumab and placebo in patients with psoriasis treated for 1 year. METHODS:Patients were randomized to gu...

journal_title：Journal of the American Academy of Dermatology

authors： Blauvelt A,Papp KA,Griffiths CE,Randazzo B,Wasfi Y,Shen YK,Li S,Kimball AB

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Many factors influence anxiety and satisfaction of patients undergoing Mohs micrographic surgery (MMS). OBJECTIVE:We sought to determine the effect of a preoperative educational telephone call on anxiety and satisfaction for patients undergoing same-day office consultation and MMS. METHODS:Patients with sk...

journal_title：Journal of the American Academy of Dermatology

authors： Sobanko JF,Da Silva D,Chiesa Fuxench ZC,Modi B,Shin TM,Etzkorn JR,Samimi SS,Wanat KA,Miller CJ

更新日期：2017-03-01 00:00:00

abstract：:Part 3 of this 4-part continuing medical education series reviews several important infectious complications of corticosteroid use, including a focus on pneumocystis pneumonia (PCP) prophylaxis, tuberculosis, viral hepatitis, and other infections, followed by a discussion of vaccination recommendations in immunosuppre...

journal_title：Journal of the American Academy of Dermatology

authors： Caplan A,Fett N,Rosenbach M,Werth VP,Micheletti RG

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Hidradenitis suppurativa (HS) is often associated with inflammatory bowel disease (IBD; Crohn's disease or ulcerative colitis). However, the prevalence of IBD in HS patients is unknown. OBJECTIVE:To determine the prevalence of IBD in HS patients, and determine if patients with HS and IBD have a distinct HS ...

journal_title：Journal of the American Academy of Dermatology

authors： Deckers IE,Benhadou F,Koldijk MJ,Del Marmol V,Horváth B,Boer J,van der Zee HH,Prens EP

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Treatment of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) remains controversial. OBJECTIVE:We sought to evaluate the impact of cyclosporine on hospital mortality in patients with SJS/TEN. METHODS:All patients with SJS and TEN admitted to our center from 2011 to 2014 were treated unde...

journal_title：Journal of the American Academy of Dermatology

authors： Lee HY,Fook-Chong S,Koh HY,Thirumoorthy T,Pang SM

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Olumacostat glasaretil (OG) inhibits acetyl-coenzyme A carboxylase, the enzyme responsible for the first, rate-limiting step in de novo fatty acid synthesis. OG inhibited in vitro human sebocyte lipid production and reduced in vivo sebaceous gland size in hamster ears. OBJECTIVES:Safety and efficacy of OG 7...

journal_title：Journal of the American Academy of Dermatology

authors： Bissonnette R,Poulin Y,Drew J,Hofland H,Tan J

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Clinical and histopathologic assessment of pigmented skin lesions remains challenging even for experts. Differentiated and accurate noninvasive diagnostic modalities are highly desirable. OBJECTIVE:We sought to provide clinicians with such a tool. METHODS:A 2-gene classification method based on LINC00518 a...

journal_title：Journal of the American Academy of Dermatology

authors： Gerami P,Yao Z,Polsky D,Jansen B,Busam K,Ho J,Martini M,Ferris LK

更新日期：2017-01-01 00:00:00

abstract：:Global temperatures continue to rise, reaching new records almost every year this decade. Although the causes are debated, climate change is a reality. Consequences of climate change include melting of the arctic ice cap, rising of sea levels, changes in precipitation patterns, and increased severe weather events. Thi...

journal_title：Journal of the American Academy of Dermatology

authors： Kaffenberger BH,Shetlar D,Norton SA,Rosenbach M

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Psoriasis is a systemic inflammatory condition that is associated with a higher risk of cardiovascular (CV) disease. Tofacitinib is being investigated as a treatment for psoriasis. OBJECTIVE:We sought to evaluate the effects of tofacitinib on CV risk factors and major adverse CV events (MACEs) in patients w...

journal_title：Journal of the American Academy of Dermatology

authors： Wu JJ,Strober BE,Hansen PR,Ahlehoff O,Egeberg A,Qureshi AA,Robertson D,Valdez H,Tan H,Wolk R

更新日期：2016-11-01 00:00:00

abstract：:Direct-to-consumer teledermatology is radically changing the way some patients obtain dermatologic care. Many direct-to-consumer teledermatology services offer care to patients younger than 18 years, but policies and standards are nonuniform. For pediatric patients, direct-to-consumer teledermatology is a substantial ...

journal_title：Journal of the American Academy of Dermatology

authors： Fogel AL,Teng J,Sarin KY

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Accurate evaluation of basal cell carcinoma (BCC) in the United States was not possible before the 2011 release of BCC-specific International Classification of Diseases, Ninth Revision, Clinical Modification codes. OBJECTIVE:We sought to describe BCC (including locally advanced BCC [LABCC]) incidence/preval...

journal_title：Journal of the American Academy of Dermatology

authors： Goldenberg G,Karagiannis T,Palmer JB,Lotya J,O'Neill C,Kisa R,Herrera V,Siegel DM

更新日期：2016-11-01 00:00:00

abstract：:Melanocytic nevi are a strong phenotypic marker of cutaneous melanoma risk. Changes in nevi during childhood and adolescence make these prime periods for studying nevogenesis. Insights gained by the study of nevi in childhood have implications for melanoma detection in both adults and children. A more comprehensive un...

journal_title：Journal of the American Academy of Dermatology

authors： Scope A,Marchetti MA,Marghoob AA,Dusza SW,Geller AC,Satagopan JM,Weinstock MA,Berwick M,Halpern AC

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:The prognostic relevance of a high blood neutrophil-to-lymphocyte ratio (NLR) has been reported in many cancers, although, to our knowledge, not investigated in patients with Merkel cell carcinoma (MCC) to date. OBJECTIVE:We assessed whether the NLR at baseline was associated with specific survival and recu...

journal_title：Journal of the American Academy of Dermatology

authors： Zaragoza J,Kervarrec T,Touzé A,Avenel-Audran M,Beneton N,Esteve E,Wierzbicka Hainaut E,Aubin F,Machet L,Samimi M

更新日期：2016-10-01 00:00:00

abstract：:Treatment with systemic immunomodulatory agents is indicated for patients with moderate to severe plaque psoriasis and psoriatic arthritis. In these patients, surgery may confer an increased risk of infectious or surgical complications. We conducted a literature review to examine studies addressing the use of methotre...

journal_title：Journal of the American Academy of Dermatology

authors： Choi YM,Debbaneh M,Weinberg JM,Yamauchi PS,Van Voorhees AS,Armstrong AW,Siegel M,Wu JJ

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Intraoperative pain during Mohs micrographic surgery (MMS) has not been characterized. However, many patients report postoperative pain on the day of MMS. OBJECTIVE:We sought to determine if patients experience pain during their MMS visit. METHODS:In phase I of this study, patients were asked to report int...

journal_title：Journal of the American Academy of Dermatology

authors： Connolly KL,Nehal KS,Dusza SW,Rossi AM,Lee EH

更新日期：2016-09-01 00:00:00

abstract：:Granuloma annulare (GA) represents a cutaneous reaction pattern of unknown cause with a variety of previously described potential disease associations and triggers. This review attempts to synthesize the available data regarding potential etiopathogenesis, reviews the available data on potential GA disease association...

journal_title：Journal of the American Academy of Dermatology

authors： Piette EW,Rosenbach M

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Paraneoplastic syndromes (PNS) are commonly associated with neuroendocrine cancers, such as small cell lung cancer. OBJECTIVES:We examined the association of PNS in Merkel cell carcinoma (MCC), a rare neuroendocrine skin cancer. METHODS:We identified PNS associated with MCC based on chart review of a Seatt...

journal_title：Journal of the American Academy of Dermatology

authors： Iyer JG,Parvathaneni K,Bhatia S,Tarabadkar ES,Blom A,Doumani R,McKenzie J,Asgari MM,Nghiem P

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Recent studies have shown a higher prevalence of cardiovascular (CV) risk factors in patients with rosacea. However, it remains unknown whether rosacea represents an independent CV risk factor. OBJECTIVE:We evaluated the risk of myocardial infarction, stroke, CV death, major adverse CV events, and all-cause...

journal_title：Journal of the American Academy of Dermatology

authors： Egeberg A,Hansen PR,Gislason GH,Thyssen JP

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Long-term adverse effects of propranolol treatment for infantile hemangioma (IH) in young children have been suggested. OBJECTIVE:To compare growth and development in children treated with propranolol for IH with nontreated healthy controls. METHODS:Eighty two (73%) children with IH aged 43 to 51 months tr...

journal_title：Journal of the American Academy of Dermatology

authors： Moyakine AV,Kerstjens JM,Spillekom-van Koulil S,van der Vleuten CJ

更新日期：2016-07-01 00:00:00

abstract：:Isotretinoin is used to treat severe and recalcitrant acne. Possible side effects include depression, suicide, and suicidal ideation; however, other studies suggest isotretinoin may improve mood and quality of life. Although iPLEDGE consenting warns about the risk of depression and suicidal ideation, there is no recom...

journal_title：Journal of the American Academy of Dermatology

authors： Schrom K,Nagy T,Mostow E

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Total body photography (TBP) can facilitate identification of new and changing lesions. By confirming that particular nevi are stable, TBP may reduce nevus biopsies. OBJECTIVES:We sought to determine the number and rate of nevus biopsies before and after TBP, and the factors associated with increased biopsy...

journal_title：Journal of the American Academy of Dermatology

authors： Truong A,Strazzulla L,March J,Boucher KM,Nelson KC,Kim CC,Grossman D

更新日期：2016-07-01 00:00:00

abstract：:Clinical trials are critical for the development of new therapies in dermatology, and their results help determine US Food and Drug Administration (FDA) approval and guide care. Of special relevance is the clinical trial efficacy end point, the metric from which statistically significant outcome is derived. Clinicians...

journal_title：Journal of the American Academy of Dermatology

authors： Wei EX,Kirsner RS,Eaglstein WH

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Paradoxical hidradenitis suppurativa (HS) induced by biologic agents (BA) is scarcely reported. OBJECTIVE:We sought to describe the clinical characteristics and outcome of patients developing paradoxical HS under BA. METHODS:This was a multicenter nationwide retrospective study asking physicians to report ...

journal_title：Journal of the American Academy of Dermatology

authors： Faivre C,Villani AP,Aubin F,Lipsker D,Bottaro M,Cohen JD,Durupt F,Jeudy G,Sbidian E,Toussirot E,Badot V,Barbarot S,Debarbieux S,Delaporte E,Goegebeur G,Morel J,Nassif A,Duru G,Jullien D,French Society of Dermatology

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Patients with rosacea have increased amounts of cathelicidin and protease activity but their usefulness as disease biomarkers is unclear. OBJECTIVE:We sought to evaluate the effect of doxycycline treatment on cathelicidin expression, protease activity, and clinical response in rosacea. METHODS:In all, 170 ...

journal_title：Journal of the American Academy of Dermatology

authors： Di Nardo A,Holmes AD,Muto Y,Huang EY,Preston N,Winkelman WJ,Gallo RL

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Malignant melanoma (MM) arising in a giant pigmented nevus (GPN) is a rare disease in adults with no large series published to our knowledge. OBJECTIVE:We sought to describe the characteristics, treatment, and survival of MM in GPN for adults. METHODS:Adults with invasive MM in GPN (n = 976) reported to th...

journal_title：Journal of the American Academy of Dermatology

authors： Turkeltaub AE,Pezzi TA,Pezzi CM,Dao H Jr

更新日期：2016-06-01 00:00:00